Sunday, September 6, 2009

MESOTHELIOMAPHYSIOLOGY

The 3 major histological types of mesothelioma are sarcomatous, epithelial, and mixed. Pleural mesothelioma usually begins as discrete plaques and nodules that coalesce to produce a sheetlike neoplasm. Tumor growth usually begins at the lower part of the chest. The tumor may invade the diaphragm and encase the surface of the lung and interlobar fissures.
The tumor may also grow along drainage and thoracotomy tracts. As the disease progresses, it often extends into the pulmonary parenchyma, chest wall, and mediastinum. Pleural mesothelioma may extend into the esophagus, ribs, vertebra, brachial plexus, and superior vena cava.
Asbestos, amphibole asbestos, asbestos-crocidolite, and amosite asbestos in particular, is the principal carcinogen implicated in the pathogenesis. Exposure to chrysotile asbestos is associated with a lower incidence of mesothelioma. The industries associated with asbestos exposure include mining, ship building involving the use of asbestos, asbestos cement manufacture, ceramics, paper milling, auto parts (asbestos brake lining), railroad repair, and insulation. In Turkey, the use of the fibrous substance erionite (similar to amphibole asbestos) in building construction has led to an epidemic of pulmonary mesothelioma. Environmental exposure to asbestos in areas polluted by the substance may increase the incidence of mesothelioma.
Most malignant mesotheliomas have complex karyotypes, with extensive aneuploidy and rearrangement of many chromosomes. A loss of a single copy on chromosome 22 is the most common abnormality.

EMEDICINESURGERY

Breast reduction is one of the most common procedures performed by plastic surgeons in North America, South America, and Europe. It is the surgical treatment of macromastia, a condition that comprises the presence of enlarged and heavy breasts.
The weight and size of breasts can be reduced by using various surgical techniques। Two main technical aspects have to be considered when detailing surgical options for reduction mammaplasty. The first one is the pattern in which to incise the skin in order to gain access to the breast parenchyma that will be removed. These skin incisions, and the skin area that is to be excised, ultimately define the location and extent of the final scars. The second aspect to be considered is the segment of breast parenchyma to be left in the patient after the glandular excision is performed. This defines the vascular and nerve supply to the remaining breast (parenchyma, draping skin, and nipple-areola complex), as well as its shape, since each area within the breast has different अत्त्रिबुतेसDiverse methods of skin incision and excision existed in the early reports of breast reduction. Some of them were improvised during the surgery, others were planned based on empiric knowledge, and a few followed complicated geometric calculations. In 1956, Robert Wise published on his experience with a refined pattern that he had previously designed in the form of a key-hole. The Wise pattern has been the workhorse for skin incision for breast reduction for several decades. It leaves an anchor-shaped scar in a periareolar circle, a vertical scar in the midline of the inferior mammary hemisphere, and a curvilinear scar along the inframammary fold that follows the curved shape of the inferior pole of the breast.
In 1972, Paul McKissock modified Wise's technique by increasing the length of the vertical limbs of the design to try to compensate for the flat lower pole that was being achieved. It is now recognized that McKissock's technique tends to result in the opposite effect, which is a bottoming-out and is not very well tolerated by patients and surgeons.
To date, the Wise pattern remains the most common method of skin excision performed in the United States, although current trends show surgeons favoring other methods that have been designed with the purpose of leaving a less extensive scar. In South America and Europe, such methods have been very well developed over the years and represent the most common method of skin incision for breast reduction. Among these shorter-scars techniques, the mosque dome pattern of skin incision has gained the greatest acceptance. It eliminates the lower curvilinear scar seen with the use of the Wise pattern, leaving only a periareolar scar and a vertical scar along the midline of the lower hemisphere of the breast. For this reason, the technique has been called vertical scar, and breast reductions using this pattern of skin incision are denominated vertical reduction mammaplasties.
The vertical scar incision pattern was originally designed by Claude Lassus in 1964 and reported in 1970, with the particularity that the inferior portion of the vertical scar ended up extending below the inframammary fold. Lassus corrected this by adding a small horizontal scar along the inframammary fold. Later on, he realized that the small horizontal scar ended up migrating up toward the lower hemisphere of the breast. He subsequently redefined his pattern of skin excision until achieving one that left only a vertical scar above the inframammary fold. This is the skin incision that is used in the so-called Lejour technique.
The advantages of this type of skin incision are that it does not leave a scar along the inframammary fold and that it leaves no risk of skin edge necrosis at the inferior pole of the breast. (Skin edge necrosis was a risk in the junction of the inverted T incision of the Wise pattern technique).
With regard to the pattern of glandular resection, the different techniques performed in breast reduction are denominated by the segment of the breast where the parenchyma is left unresected, which becomes the structure and support of the new breast. This area also contains the vascular pedicle that will supply the breast, including the nipple-areola complex. For these reasons, techniques are denominated superior, superomedial, medial, inferior, lateral, or central pedicles. Bipedicle techniques, which include either superior and inferior or lateral and medial aspects of the breast, are also used.
Each technique has advantages and disadvantages. The superior pedicle method (which involves the resection of the medial, lateral, and inferior portions of the breast parenchyma) was originally described by Daniel Weiner in 1973. Initially, it gained more popularity in Europe than in North and South America. It was thought to put at risk the sensation of the nipple-areola complex because of the belief that it transected the lateral branches of the fourth intercostal nerve. The sensory branches to the nipple-areola complex are now known to run deep at the level of the chest wall and perforate superficially through the breast parenchyma to reach to nipple areola complex. For this reason, keeping parenchymatous resections just above the level of the chest wall preserves the nerve supply to the nipple-areola complex and, thus, its sensation.
Another reason for which this method of parenchyma resection was not widely approved was the thinking that the vascular pedicle may get kinked or compressed while folding the dermoglandular portion of the breast over to inset the areola up on its new location. Currently, good evidence exists supporting the knowledge that the breast is adequately supplied by the superior dermoglandular pedicle that results as a consequence of this pattern of parenchyma resection.
For this reason, trends exist in North America and South America toward performing superior pedicle techniques of breast reduction more often than in the past. This is the pattern of parenchymatous excision used in the Lejour technique. Its advantages are that it preserves the area that is less prone to undergo further ptosis secondary to downward pulling action of gravity, as well as maintaining fullness in the upper pole of the breast while allowing for small, medium, and large resections.
In 1994, Madeleine Lejour reported on 153 reduction mammaplasties using this technique in 79 patients. Later, she updated her experience on 324 reductions performed in 167 patients. Several studies on the use of this technique have been published since.

Presentation
Patients with macromastia present to the clinic with enlarged breasts that tend to be ptotic and that cause chest, neck, back and shoulder pain; difficulty performing deep inspirations; and the inability to fit into proper clothing. Patients may show shoulder indentations from the brassiere and inframammary intertrigo.
A complete medical history has to be obtained, including age, information on childbearing and breastfeeding, future pregnancy and nursing plans, smoking history, concomitant diseases, history of breast diseases and surgery, family history of breast cancer, medication allergies, and tendency to bleed.
Physical examination should focus on body mass index, vital signs, breast masses, inframammary intertrigo, degree of breast enlargement and ptosis, skin lesions, and nipple sensation and discharge.

MESOTHELIOMAMEDICALTREATMENT

Medical Therapy
Some of the symptoms related to macromastia may show some improvement with analgesics, but definitive treatment of macromastia is entirely surgical.
Surgical Therapy
The Lejour technique involves a vertical reduction based on a superior pedicle and includes breast liposuction and wide lower skin undermining.
Preoperative Details
Before the surgery, pictures are taken in different views. The sternal notch – to-nipple distances and the nipple-to – inframammary fold distances are recorded and documented properly. Patients are instructed on the purposes of the procedure, the goals that may be achieved, the expected final size and shape of the breasts, the expected final appearance of the scars, changes in nipple sensations, changes in the ability to breastfeed, and possible complications. Patients are instructed on what to expect during their recovery period and on proper wound care.
While the patient is standing, the technique begins by marking the patient with the mosque dome pattern of skin incision and the area that represents the superior dermoglandular pedicle. Markings are placed in the breast midline, the inframammary fold, and the vertical axis of the breast beneath the inframammary fold. The upper edge of the future areola is marked slightly below the level of the inframammary fold, and a semi-circumference no larger than 16 cm is marked. By displacing the breast medially and laterally in relation to its vertical axis, the peripheral limbs are marked, joining together no less than 5 cm above the inframammary fold. The future areolar circumference is marked around the nipple. A minimum of 10 cm of superior pedicle width is marked at the upper border of the future areola and continued in a conical shape down around the marked circumference.

Intraoperative Details
After markings are done, patients are placed symmetrically on the operating room table with arms abducted and secured to allow intraoperative placement in a semisitting position. Draping is also performed symmetrically to provide an accurate assessment of postoperative breast symmetry. A dose of prophylactic antibiotic is administered. The breasts are injected with lidocaine and epinephrine, the pedicle epidermis that surrounds the areola is excised, and fat from the breast tissue is suctioned. Next, the medial, lower, and lateral segments of the breast are resected, with undermining of the skin below the lower curved marking. Resected tissue is sent for histopathology inspection, since subclinical foci of cancer can be found in 0.1-0.9% of the specimens.
Next, the nipple-areola complex is inset, the parenchymatous pillars are approximated, and the skin is closed. Current evidence suggests that drains can be avoided, since the incidence of collections and wound healing events are the same with or without their use.
Postoperative Details
Dressings may vary with surgeon preference and include adhesive strips of tape, liquid skin adhesive, gauzes, pads, tape, and supporting brassieres. Patients are told to ambulate and resume light diet the same day of the surgery. They can shower the day after the surgery but should avoid strenuous physical activity and should wear a sports brassiere.
Follow-up
Regular visits are scheduled to ensure an adequate outcome and provide early identification and proper care of possible complications. The wrinkles at the bottom of the vertical scar usually fade away in 1-6 months, although some surgical revision of this area might be required.

MESOTHELIOMA MESOLINK

Mesothelioma is one of the deadliest diseases known to man; the average life span of an inflicted person from the time of diagnosis until death is less than 24 months. It’s a disease that strikes approximately 3,000 United States citizens each and every year; hard working people who have labored for a lifetime to provide for their families, doing the work that keeps this country running and a great place to live. They worked in factories, at shipyards, in mines, for the US military, as engineers, as pipefitters, as steel workers, as auto mechanics, and in so many other professions. They came home to their loved ones exhausted and covered in dirt and dust; tired, but content that they had a job and were providing for their family. Content that they were putting food on the table and a house over their loved one’s heads. Content that they were working to make a better life for their families in this generation and the next...

But what they didn’t know was that while they were working so hard, they were not only slowly killing themselves, but those that they were working so hard to help; their family, their loved ones.